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Reactive astrocytes may also be stimulated by specific signaling cascades to gain detrimental effects such as the following: [3] [14] Exacerbation of inflammation via cytokine production Production and release of neurotoxic levels of reactive oxygen species Release of potentially excitotoxic glutamate The potential contribution to seizure genesis Compromise of bloodbrain barrier function as a result of vascular endothelial growth factor production Cytotoxic edema during trauma and stroke through AQP4 overactivity Potential for chronic cytokine activation of astrocytes to contribute to chronic pain Reactive astrocytes have the potential to promote neural toxicity via the generation cytotoxic molecules such as nitric oxide radicals and other reactive oxygen species, [7] which may damage nearby neurons

They can be included in breakfast dishes, salads, or enjoyed as snacks

Also, glymphatic impairment could induce oxidative stress and inflammation, contributing to depressive disorders [102]

Nutrition: Keep protein intake adequate and overall diet balanced to support metabolism and lean mass